Logo for the Journal of Rehab R and D

JRRD at a Glance

Sustained antinociceptive effect of cannabinoid receptor agonist WIN 55,212-2 over time in rat model of neuropathic spinal cord injury pain

Aldric Hama, PhD; Jacqueline Sagen, PhD

Figure. Dose-response to WIN 55,212-2 (WIN) 30 min after injection in rats with spinal cord injury (n = 5-6 rats/group).

Chronic pain after spinal cord injury (SCI) is a complication that significantly diminishes the patient's quality of life. Few drugs effectively alleviate this type of pain, and those that do may lose effectiveness with repeated use. Cannabinoid drugs have been shown to be useful in treating experimental pain in animal models and also appear to maintain their effectiveness with repeated treatment in SCI pain. As part of a comprehensive rehabilitation program, cannabinoids may help ease pain and increase quality of life for persons with SCI.


Volume 46 Number 1, 2009
   Pages 135 — 144

View HTML   ¦    View PDF   ¦    Contents Vol. 46, No. 1