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Supplement Number 1
Volume 42 Number 3, May/June 2005
Pages vii — xiv

Guest Editorial:
Background on the 3rd International Congress "Restoration of (wheeled) mobility in SCI rehabilitation": State of the art III


Lucas H. V. van der Woude, PhD; Thomas W. J. Janssen, PhD; Dirk Jan Veeger, PhD

INTRODUCTION

"Restoration of (wheeled) mobility in SCI rehabilitation" was the theme of a recent International Congress in Amsterdam, April 2004. Restoration of mobility in spinal cord injury (SCI) in its ultimate form would be to remove the cause of the mobility limitation, i.e., curing the SCI. Despite a large and basic research effort on neural regeneration on spinal cord repair and on damage preventive-early intervention-strategies [1-2], no cure is available today for spinal cord damage. In contrast to the strong financial research stimuli and the growing expectations on the success of neural repair as a cure for SCI, today's reality is that SCI is not curable.

SCI has long-term and far-fetching consequences for daily functioning and freedom of mobility. As such, an inevitable need exists for applied and basic research into SCI rehabilitation; into its goals, strategies, and practices; and where possible, into new and innovative avenues of care improvement. This need was the focus of the 3rd International Congress "Restoration of (wheeled) mobility in SCI rehabilitation: state of the art III." The following is a retrospective, both on the evolution of the research work of the research group at the Faculty of Human Movement Sciences in Amsterdam that formed the basis for the program themes as well as a personal opinion on the research issues that are currently evolving from the rehabilitation field within the framework of restoration of mobility.

MOBILITY

Although mobility is an essential element in daily living, its importance is usually only recognized when it is for some reason (temporarily) limited. Mobility is a multilayered concept. One can speak of joint mobility, but also of mobility as a form of daily activity, and even within the context of participation, we use the term mobility. All three mentioned connotations of mobility substantiate main objectives of an integral rehabilitation process. As such, mobility can be positioned at each of the three domains of functioning within the International Classification of Functioning, Disability and Health (ICF) model [3]. This model is in many ways the starting point of research activities that are briefly reviewed in this paper (Figure 1).


Figure 1. International Classification of Functioning, Disability and Health (ICF) model - health in spinal cord injury.

Within the context of a chronic impairment, rehabilitation focuses on restoration of locomotion, ambulation, or mobility in its widest sense. Continuing to be a mobile individual and having an optimal social and physical range of action are key objectives in SCI rehabilitation. In today's rehabilitation field, this goes beyond the mere restoration, compensation, and (technology-based) adaptation of sensor-motor function, activities of daily living (ADLs) functionality, and independence. Having a physically active lifestyle during and after rehabilitation is becoming an issue on the rehabilitation research agenda [4-7].

THE INTERNATIONAL CONGRESS

The central theme of the 3rd International Congress was the restoration of mobility in SCI. The meeting was focused on combining knowledge of exercise regimes, practice modes, learning and training protocols, rehabilitation strategies, and front-edge assistive technology. Understanding of the underlying mechanisms and processes of adaptation and/or compensation of function and functioning (with or without the use of optimal assistive technology) is the core of rehabilitation research. The rehabilitation paradigm can be summarized as "to restore function and functionality and to stimulate optimal activity and participation," a multicausal and multilayered concept. As a theoretical framework, the ICF model was taken as a starting point for the program of the 3rd International Congress: mobility and function, mobility and activity, and mobility and participation, respectively. Issues that were addressed were as diverse as hand-arm functionality, including orthotics and functional electrical stimulation (FES); treadmill walking; FES cycling; hand-cycling; wheelchair propulsion; seating; physical activity and life style; mobility-related secondary health problems; functional independ-ence; quality of life; well-being; cultural and immigrant background; and participation. A sample of the excellent presentations and research work performed can be found in this special issue.

The history of the 3rd International Congress dates to the early 1990s and explains the adjective "(wheeled)" in the title of the Congress. In 1991, a first international scientific workshop on wheeled mobility was held at the Vrije Universiteit, Amsterdam. This first workshop was fully dedicated to manual wheelchair propulsion [8]. The second workshop was held again at the Vrije Universiteit in Amsterdam in 1998 and focused on (wheeled) mobility issues and questions on SCI rehabilitation [9]. The 3rd International Congress can be viewed as a further widening of the scope from wheeled mobility to a broader concept of mobility.

FROM WHEELCHAIR RESEARCH TO A MULTIDISCIPLINARY PROGRAM

The scope of the 3rd International Congress has undergone a parallel development as the work on wheelchair propulsion since 1983 at the Faculty of Human Movement Sciences in Amsterdam, the host for all three meetings. This research line started with a combined physiological and biomechanical approach into the optimization of wheelchair propulsion ability [10-11]. Different performance-influencing aspects, especially the ergonomics of the wheelchair-user interface, individual physical work capacity, and various aspects of propulsion technique, were studied, as well as aspects of vehicle mechanics. Recently, biophysical aspects of the learning process of hand-rim wheelchair propulsion were incorporated [12], and hand-cycling as a more efficient alternative mode of ambulation became part of the research topics [13-14]. With the increasing understanding of wheelchair mobility came a growing interest in the mechanical consequences of long-term wheelchair use: the quest for the mechanisms and consequences of musculoskeletal overuse in wheelchair use and ADL [13-17], especially in those with SCI. Apart from longitudinal research, in which epidemiological and experimental techniques are combined, this problem requires the use of detailed techniques for kinematics and kinetic [11,18-19], as well as upper-limb modeling tools [17,20-21].

ASSISTIVE TECHNOLOGY

The interaction between assistive technology and the (disabled) human system is complex by definition and requires detailed research from a combined ergonomics and rehabilitation perspective. As an example, the long-term use of assistive technology and its consequences on the musculoskeletal system has become an important issue in manual wheelchair research, where the continued imbalance between the task stresses, physical strain, and overall mechanical and physiological work capacity leads to overuse of and injuries in the upper limb [22]. Also if assistive technology for mobility and the biological system do not function optimally, a debilitative cycle may start that can lead to an inactive lifestyle and consequently to a possible increased risk for secondary impairments, such as cardiovascular disease [23-24]. This stresses the important preventive role of an ergonomics approach within the field of rehabilitation and assistive technology.

Within the broader context of reactivation and restoration of mobility in SCI, biotechnical-oriented SCI research recently evolved not only in the field of wheeled mobility but also with walking, i.e., body-weight-supported treadmill walking [25-26] and the use of gait-assisting robotics. Also, robotics in ADL and upper-limb support [27-28] and the upper-limb neuroprostheses for those with tetraplegia [29-31] are examples of specific assistive technology that support restoration of function and functionality in SCI. Electrically stimulated (ES) cycling has been in the field for two decades. The therapeutic use of stationary recumbent ES bicycles in SCI has become common in some countries and has stimulated the development of technology for ES recumbent cycling in real life [32-35], allowing a more active lifestyle even in high-lesion SCI. These devices will require the input of an ergonomics-oriented research to reach an optimal long-term functioning of the "assistive technology-user" combination.

(IN)ACTIVITY

After the importance of a physically active lifestyle was recognized for the general population through research [35-38] and by influential (political) bodies such as the American College of Sports Medicine,1 Center for Disease Control,2 and World Health Organization,3 evidence was found that (restoration of) an active lifestyle is probably even more important for those with a chronic disease or those involved in (clinical) rehabilitation [4-7,39].

The focus on the health-related mobility problem of a wheelchair-confined life in individuals with SCI was recognized by Hjeltnes and Vokac [23] and later initiated in our research group by Janssen et al. and Dallmeijer et al. [24,40-41]. More and more, the risks of a sedentary lifestyle have become apparent in international literature as being one of the keystones to many chronic diseases, such as type-2 diabetes, syndrome X, or cardiovascular disease [4-7,39]. The prominent role of physical activity and lifestyle in the development or, better, prevention of long-term health problems has become a specific issue that is clearly translated into the Congress program theme and will have to be on the rehabilitation research agenda.

Apart from the common use of questionnaires for (in)activity and lifestyle research, the use of small computer-based activity sensors has also entered activity monitoring in the field of rehabilitation [42-44]. Only few physical activity questionnaires are available for specific use in rehabilitation populations [39], while the more complex sensor techniques require elaborate validation and reliability research for different subpopulations. They do allow, however, observing the quantity as well as quality of ambulation in real life over a longer period of time, thus opening ways to stimulate and advise on activity and lifestyle, as well as quality of movement [42-44].

FROM OUTPATIENT TO INPATIENT RESEARCH

For the Faculty of Human Movement Sciences, at a Dutch university, the transfer from outpatient to inpatient rehabilitation research was a major step that only became possible with the close collaboration with local rehabilitation centers, especially the Rehabilitation Center Amsterdam.4 SCI research within the Faculty of Human Movement Sciences and Institute for Fundamental and Clinical Human Movement Sciences over the years shifted away somewhat from the "wheelchair core business" only, toward other forms of locomotion (i.e., hand-cycling and electrical-stimulation-induced leg-cycling) and more fundamental issues of cardiovascular adaptation [45-47], muscle physiology [48], and biomechanical upper-limb modeling [16-17,21]. Apart from changes in the biology due to the initial paralysis, long-term effects of chronic inactivity in SCI are studied, as well as the restoring effects of lower-body exercise. The latter is often in the form of electrically stimulated leg-cycling [49] and addresses both cardiovascular adaptation and muscle physiological aspects. The importance of more systematic research into underlying biological processes and mechanisms of adaptation and compensation of function and functioning in SCI is evidently expressed in this special issue, but also in today's literature.

RESTORATION OF MOBILITY IN SCI REHABILITATION: A RESEARCH PROGRAM

The 2004 Congress also has its roots in the multidisciplinary research program "Functional strain, work capacity and restoration of mobility in the rehabilitation of persons with a spinal cord injury,"5 which was initiated in 1998 and naturally evolved from the earlier wheelchair and SCI research. This program, in short, "Restoration of mobility in SCI rehabilitation," is a multicenter collaboration among five research groups, SCI units of eight rehabilitation centers in the Netherlands, and the Dutch-Flemish Society of Paraplegia (NVDG).6

The multicenter program is presently formed by 12 complementary research projects, which cover various aspects of restoration of mobility in its broadest context. The benefits of such a long-term multidisciplinary collaboration and the availability of larger numbers of subjects are evident. The development of this multidisciplinary program was only possible given the special infrastructure of Dutch rehabilitation healthcare and densely populated Dutch society, with the financial support of Rehabilitation Program of ZONmw,7 a national organization that promotes quality and innovation in the field of health research and healthcare.

This in turn facilitates the structured implementation of newly developed knowledge in the healthcare system and guarantees emerging healthcare issues a place on the research agenda. The backbone of the research program is formed by a prospective-cohort study. Over 200 patients with SCI during and 1 year after initial rehabilitation performed a series of function and functional tests. The project measures each patient four times with a standardized array of questionnaires and tests-among which arm-hand function tests in those with tetraplegia, a wheelchair skills test and maximum wheelchair exercise test on a motor driven treadmill (Figure 2), and a walking test in those with an incomplete lesion-and questionnaires covering many different aspects at each level of the ICF model. Understanding the complexity of restoration of mobility in SCI   requires large subject numbers, combined experimental and epidemiological studies over time, and complex multilevel statistical techniques [13,30,50-53]. A strong need exists for such large group multidisciplinary prospective studies in rehabilitation for theory development and the evidence-base of treatment [54], from which future intervention studies as well as experimental studies must be derived. Some of the initial program results are presented in this special issue.


Figure 2. A maximal wheelchair exercise test on a motor-driven treadmill.
CONCLUSION

Clearly, rehabilitation research has a need for multidisciplinary collaboration and exchange to tackle the (methodological) research questions and practical problems of today and to be prepared for the issues of tomorrow. An in-depth understanding of the origin and consequences of impaired function and functionality, the opportunities for treatment, and the prevention of secondary problems often requires not only multicenter and longitudinal collaboration but also the multidisciplinary approach of experimental and intervention studies. Research into assistive technology for mobility must address the optimization of the interaction of the biological system to prevent long-term health problems as a consequence of overuse. This and other issues require both specific and generic measurement tools and technology. International Congress activities will contribute to these goals and processes.

ACKNOWLEDGMENTS

The members of the Congress organization team (Edmond D. L. Angenot, Kirsten E. Bijker, Stefan van Drongelen, Timon van der Scheer, and Marjan Schot) and the scientific committee (Floris W. A. van Asbeck, Rita van den Berg, Michael Bergen, Hans Bussmann, Annet J. Dallmeijer, Sonja de Groot, Maria T. E. Hopman, Dirk J. M. van Kuppevelt, Anand V. Nene, Cees Pons, Marcel Post, Henk A. M. Seelen, Hans R. Slootman, Tebbe A. R. Sluis, Govert J. Snoek, and Maarten J. IJzerman) are greatly acknowledged for their effort and input into the success of the 3rd International Congress.

Lucas H. V. van der Woude, PhD; Thomas W. J. Janssen, PhD; Dirk Jan Veeger, PhD
REFERENCES
1. Department of Veterans Affairs, Rehabilitation Research and Development Service. 10th International Symposium on neural regeneration. J Rehabil Res Dev. 2003;40(6 Suppl 3): 1-62.
2. Vehaagen J. Cell and gene therapy strategies to promote repair of the injured rat spinal cord. J Rehabil Res Dev. 2004; 41(2 Suppl 2):15-16.
3. World Health Organization. International Classification of Functioning, Disability and Health, 2001. Geneva (Switzerland); World Health Organization; 2001.
4. Cooper RA, Quantrano LA, Axelson PW, Harlan W, Stineman M, Franklin B, Krause JS. Research on physical activity and health among people with disabilities: a consensus statement. J Rehabil Res Dev. 1999;36(2):142-54.
5. Durstine JL, Moore, GE, editors. ACSM's exercise management for persons with chronic diseases and disabilities. 2nd ed. Champaign (IL): Human Kinetics; 2003.
6. Frontera WR, editor. Exercise in rehabilitation medicine. Champaign (IL): Human Kinetics; 1999.
7. Rimmer JH, Braddock D. Health promotion for people with physical, cognitive and sensory disabilities: an emerging national priority. Am J Health Promot. 2002;16(4): 220-24.
8. van der Woude LH, de Boer YA, van der Grinten BA, Meijs PJM, editors. Ergonomics of manual wheelchair propulsion, state of the art. Amsterdam: IOS press; 1993.
9. van der Woude LH, Hopman M, Van Kemenade CH. Biomedical aspects of manual wheelchair propulsion: state of the art II. Amsterdam: IOS press; 1999.
10. van der Woude LH, de Groot G, Hollander AP, van Ingen Schenau GJ, Rozendal RH. Wheelchair ergonomics and physiological testing of prototypes. Ergonomics. 1986; 29(12):1561-73.
11. Veeger HE, van der Woude LH, Rozendal RH. A computerized wheelchair ergometer. Results of a comparison study. Scand J Rehabil Med. 1992;24(1):17-23.
12. de Groot S, Veeger HE, Hollander AP, van der Woude LH. Influence of task complexity on mechanical efficiency and propulsion technique during learning of hand rim wheelchair propulsion. Med Eng Phys. 2005;27(1):41-49.
13. Dallmeijer AJ, Ottjes L, de Waardt E, van der Woude LHV. A physiological comparison of synchronous and asynchronous hand cycling. Int J Sports Med. 2004;25(8):622-26.
14. Janssen TW, Dallmeijer AJ, van der Woude LH. Physical capacity and race performance of handcycle users. J Rehabil Res Dev. 2001;38(1):33-40.
15. Boninger ML, Impink BG, Cooper RA, Koontz AM. Relation between median and ulnar nerve function and wrist kinematics during wheelchair propulsion. Arch Phys Med Rehabil. 2004;85(7):1141-45.
16. van Drongelen S, van der Woude LHV, Janssen TW, Angenot EL, Chadwick EK, Veeger DH. Mechanical load on the upper extremity during wheelchair activities. APMR. 2005;86:1214-20.
17. Veeger HE, Rozendaal LA, van der Helm FC. Load on the shoulder in low intensity wheelchair propulsion. Clin Biomech. 2002;17(3):211-18.
18. Asato KT, Cooper RA, Robertson RN, Ster JF. SMARTWheels: development and testing of a system for measuring manual wheelchair propulsion dynamics. IEEE Trans Biomed Eng. 1993;40(12):1320-24.
19. Robertson RN, Boninger ML, Cooper RA, Shimada SD. Pushrim forces and joint kinetics during wheelchair propulsion. Arch Phys Med Rehabil. 1996;77(9):856-64.
20. Shimada SD, Cooper RA, Boninger ML, Koontz AM, Corfman TA. Comparison of three different models to represent the wrist during wheelchair propulsion. IEEE Trans Neural Syst Rehabil Eng. 2001;9(3):274-82.
21. Rozendaal LA, Veeger HE. Force direction in manual wheel chair propulsion: balance between effect and cost. Clin Biomech. 2000;15 Suppl 1:S39-41.
22. Boninger ML, Cooper RA, Fitzgerald SG, Lin J, Cooper R, Dicianno B, Liu B. Investigating neck pain in wheelchair users. Am J Phys Med Rehabil. 2003;82(3):197-202
23. Hjeltnes N, Vokac Z. Circulatory strain in everyday life of paraplegics. Scand J Rehabil Med. 1979;11(2):67-73.
24. Janssen TWJ, van Oers CA, Rozendaal EP, Willemsen EM, Hollander AP, van der Woude LHV. Changes in physical strain and physical capacity in men with spinal cord injuries. Med Sci Sports Exerc. 1996;28(5):551-59.
25. Dietz V, Colombo G. Recovery from spinal cord injury-underlying mechanisms and efficacy of rehabilitation. Acta Neurochir. 2004;89 Suppl:95-100.
26. Herman R, He J, D'Luzansky S, Willis W, Dilli S. Spinal cord stimulation facilitates functional walking in a chronic, incomplete spinal cord injured. Spinal Cord. 2002;40(2): 65-68.
27. Hammel J, Hall K, Lees D, Leifer L, Van der Loos M, Perkash I, Crigler R. Clinical evaluation of a desktop robotic assistant. J Rehabil Res Dev. 1989;26(3)1-16.
28. Lum PS, Burgar CG, Shor PC, Majmundar M, Van der Loos M. Robot-assisted movement training compared with conventional therapy techniques for the rehabilitation of upper-limb motor function after stroke. Arch Phys Med Rehabil. 2002;83(7)952-59.
29. Bryden AM, Wuolle KS, Murray PK, Peckham PH. Perceived outcomes and utilization of upper extremity surgical reconstruction in individuals with tetraplegia at model spinal cord injury systems. Spinal Cord. 2004;42(3):169-76.
30. Kilgore KL, Peckham PH, Keith MW, Montague FW, Hart RL, Gazdik MM, Bryden AM, Snyder SA, Stage TG. Durability of implanted electrodes and leads in an upper-limb neuroprosthesis. J Rehabil Res Dev. 2003;40(6):457-68.
31. Wuolle KS, Bryden AM, Peckham PH, Murray PK, Keith M. Satisfaction with upper-extremity surgery in individuals with tetraplegia. Arch Phys Med Rehabil. 2003;84(8): 1145-49.
32. Berkelmans R, Duysens J, Kuppevelt HJM. The development of a hybrid FES bike. J Rehabil Res Dev. 2004;41 (2 Suppl 2):S54.
33. Fornusek C, Davis GM. Technical design of a novel isokinetic FES exercise bicycle for spinal cord injured individuals. J Rehabil Res Dev. 2004;41(2 Suppl 2):S53.
34. Gfohler M, Loicht M, Lugner P. Exercise tricycle for paraplegics. Med Biol Eng Comput. 1998;36(1):118-21.
35. Reichenfelser W, Gfohler M, Angeli T. Design of a test-and-training tricycle for paraplegics. J Rehabil Res Dev. 2004;41(2 Suppl 2):S28-29.
36. Brown DR, Pate RR, Pratt M, Wheeler F, Buchner D, Ainsworth B, Macera C. Physical activity and public health: training courses for researchers and practitioners. Public Health Rep. 2001;116(3):197-202.
37. Haskell WL. JB Wolffe Memorial Lecture. Health consequences of physical activity: understanding and challenges regarding dose-response. Med Sci Sports Exerc. 1994; 26(6):649-60.
38. Haskell WL. Physical activity, sport, and health: toward the next century. Res Q Exerc Sport. 1996;67(3 Suppl): S37-47.
39. van der Ploeg HP, van der Beek AJ, van der Woude LHV, Mechelen W. Physical activity for people with a disability: a conceptual model. Sports Med. 2004;34(10):639-49.
40. Dallmeijer AJ, Hopman MT, van der Woude LHV. Lipid, lipoprotein, and apolipoprotein profiles in active and sedentary men with tetraplegia. Arch Phys Med Rehabil. 1997;78(11):1173-76.
41. Janssen TW, van Oers CA, van Kamp GJ, TenVoorde BJ, van der Woude LH, Hollander AP. Coronary heart disease risk indicators, aerobic power, and physical activity in men with spinal cord injuries. Arch Phys Med Rehabil. 1997; 78(7):697-705.
42. Bussmann HB, Reuvekamp PJ, Veltink PH, Martens WL, Stam HJ. Validity and reliability of measurements obtained with an "activity monitor" in people with and without a transtibial amputation. Phys Ther. 1998;78(9):989-98.
43. Nunn A, McLeod J, Brown I, Ting A, Hayes C, Earley E, Hawkins R. Monitoring patients with SCI during activity using a datalogger. J Rehabil Res Dev. 2004;41(2 Suppl 2): S47.
44. Smith DG, Domholdt E, Coleman KL, Del Aguila MA, Boone DA. Ambulatory activity in men with diabetes: Relationship between self-reported and real-world performance-based measures. J Rehabil Res Dev. 2004; 41(4):571-80.
45. Hopman MT, Groothuis JT, Flendrie M, Gerrits KH, Houtman S. Increased vascular resistance in paralyzed legs after spinal cord injury is reversible by training. J Appl Physiol. 2002;93(6):1966-72.
46. Hopman MT, Houtman S, Groothuis JT, Folgering HT. The effect of varied fractional inspired oxygen on arm exercise performance in spinal cord injury and able-bodied persons. Arch Phys Med Rehabil. 2004;85(2):319-23.
47. Hopman MT, Monroe M, Dueck C, Phillips WT, Skinner JS. Blood redistribution and circulatory responses to submaximal arm exercise in persons with spinal cord injury. Scand J Rehabil Med. 1998;30(3):167-74.
48. Gerrits HL, Hopman MT, Offringa C, Engelen BG, Sargeant AJ, Jones DA, Haan A. Variability in fibre properties in paralysed human quadriceps muscles and effects of training. Pflugers Arch. 2003;445(6):734-40.
49. Janssen TW, Bakker M, Wyngaert A, Gerrits KH, de Haan A. Effects of stimulation pattern on electrical stimulation-induced leg cycling performance. J Rehabil Res Dev. 2004;41(6A):787-96.
50. Kilkens OJ, Dallmeijer AJ, Nene AV, Post MW, van der Woude LHV. Longitudinal development of manual wheelchair skill performance during inpatient rehabilitation of persons with a spinal cord injury: associations with subject characteristics, lesion characteristics, secondary complications and co-morbidity. Arch Phys Med Rehabil. In press 2005.
51. Kilkens OJ, Dallmeijer AJ, De Witte LP, van der Woude LH, Post MW. The Wheelchair Circuit: Construct validity and responsiveness of a test to assess manual wheelchair mobility in persons with spinal cord injury. Arch Phys Med Rehabil. 2004;85(3):424-31.
52. Kilkens OJ, Post MW, Dallmeijer AJ, Seelen HA, van der Woude LH. Wheelchair skills tests: a systematic review. Clin Rehabil. 2003;17(4):418-30.
53. Kilkens OJ, Dallmeijer AJ, de Witte LP, van der Woude LH, Post MW. The wheelchair circuit: reliability of a test to assess mobility in persons with spinal cord injuries. Arch Phys Med Rehabil. 2002;83(12):1783-88.
54. Marino RJ, Ditunno JF Jr, Donovan WH, Maynard F Jr. Neurologic recovery after traumatic spinal cord injury: data from the Model Spinal Cord Injury Systems. Arch Phys Med Rehabil. 1999;80(11):1391-96.
1www.acsm.org
2www.cdc.gov/nccdphp/dnpa/surveill.htm
3www.who.int/hpr/physactiv/health.benefits.shtml
4www.rcamsterdam.nl
5www.fbw.vu.nl/onderzoek/A4zon/ZONenglish
6www.nvdg.org
7ZONmw, Netherlands Organization for Health Research and Development, www.zonmw.nl

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