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Volume 43 Number 1, January/February 2006
Pages 73 — 82

Abstract - Correlations of Perceived Deficits Questionnaire of Multiple Sclerosis Quality of Life Inventory with Beck Depression Inventory and neuropsychological tests

Jesus Lovera, MD, MSPH;1-2* Bridget Bagert, MD, MPH;3 Kyle H. Smoot, MD;2 Katherine Wild, PhD;2 Rachel Frank, BA;2 Kristin Bogardus, BS;2 Barry S. Oken, MD;2 Ruth H. Whitham, MD;1-2 Dennis N. Bourdette, MD1-2

1Multiple Sclerosis Center of Excellence West, Portland Department of Veterans Affairs (VA) Medical Center,
Portland, OR; 2Department of Neurology, Oregon Health & Science University School of Medicine, Portland, OR; 3Department of Environmental Health, Harvard School of Public Health, Cambridge, MA
Abstract — The Perceived Deficits Questionnaire (PDQ) is a part of the Multiple Sclerosis (MS) Quality of Life Inventory that assesses self-perceived cognitive difficulties. We used baseline data from 49 MS subjects participating in a clinical trial to evaluate the correlation of the PDQ with two measures of cognitive impairment, the Paced Auditory Serial Addition Test (PASAT) and the California Verbal Learning Test, 2nd edition (CVLT-II), total score, and one measure of depression, the Beck Depression Inventory-Amended (BDI-IA). The PDQ correlated significantly (r = 0.42; 95% confidence interval [CI], 0.15 to 0.62; p = 0.003) with the BDI-IA scores but not with either the PASAT (r = -  0.22; 95% CI, -  0.48 to 0.06; p = 0.2) or the CVLT-II total (r = -  0.17; 95% CI, - 0.43 to 0.12; p = 0.25). A subset of 38 of these subjects who scored worse than 0.5 standard deviation below the mean on the PASAT or CVLT-II received a more extensive neuropsychological battery of tests. No significant correlations were found between any of these tests and the PDQ. These results suggest that self-perceived cognitive dysfunction relates more to depression than to objective cognitive dysfunction.
Key words: Beck Depression Inventory, California Verbal Learning Test, cognition disorders, depression, multiple sclerosis, neuropsychological tests, Paced Auditory Serial Addition Test, Perceived Deficits Questionnaire, quality of life, questionnaires.

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