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Volume 43 Number 2, March/April 2006
Pages 219 — 226

Abstract - Experimental wound healing using microamperage electrical stimulation in rabbits

Mohammad Bayat, PhD;1* Zahra Asgari-Moghadam, BSc;2 Mohammad Maroufi, PhD;3 Fatemeh-Sadat Rezaie, BSc;4 Maryam Bayat, MD;5 Mohammad Rakhshan, MD6

1Cell and Molecular Biology Research Center and Departments of Anatomy, 2Physiotherapy, Shaheed Beheshti University of Medical Sciences, Tehran, Iran (Islamic Republic of); 3Department of Physiotherapy, Iran University of Medical Sciences, Tehran, Iran (Islamic Republic of); 4Royal Institute, Tehran, Iran (Islamic Republic of); 5Islamic Azad University, Tehran, Iran (Islamic Republic of); 6Department of Pathology, Shaheed Beheshti University of Medical Sciences, Tehran, Iran (Islamic Republic of)
Abstract — We investigated the effects of microamperage electrical stimulation (MES) on the healing of skin incision in rabbits. Thirty male adult rabbits were randomly divided into sham-treated and experimental groups. Each group was divided into three subgroups, based on the duration of experiment (4, 7, and 15 days). A full-thickness incision was made on the skin of each rabbit. The experimental group received an MES of 200 microamperes current intensity for 2 h/day. Morphometrical and biomechanical evaluations were carried out. The mean number of fibroblasts at day 7 and the mean of tensile strength at day 15 were found to be significantly higher for the experimental group than for those in the sham-treated group (p < 0.01 and p < 0.05, respectively). Daily application of MES significantly accelerated the wound-healing process of full-thickness incision in the rabbits' skin.
Key words: biomechanical evaluation, electrotherapy, fibroblast, histology, microamperage current, morphometry, rabbits, skin incision, tensile strength, wound healing.

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