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Logo for the Journal of Rehab R&D
Volume 43 Number 4, July/August 2006
Pages 573 — 580


Abstract - Skin and bone integrated prosthetic pylon: A pilot animal study

Mark Pitkin, PhD;1-2* Grigory Raykhtsaum;2 Oleg V. Galibin, MD, PhD;3 Mikhail V. Protasov, MD;3
Julie V. Chihovskaya, MD;3 Irina G. Belyaeva, MD, PhD3

1Department of Physical Medicine and Rehabilitation, Tufts University School of Medicine, Boston, MA;
2Poly-Orth International, Sharon, MA; 3Department of Experimental Medicine, I. P. Pavlov State Medical
University, St. Petersburg, Russia
Abstract — Direct skeletal attachment of limb prostheses is a viable alternative to traditional techniques that are based on a socket-residuum interface. Direct skeletal attachment may be a better or even the only method for patients with a very short residuum and high soft-tissue volume. The problem of integrating the prosthetic pylon with residual skin during direct skeletal attachment of a limb prosthesis has not been solved, and the use of a completely porous prosthetic pylon has not been the subject of focused, systematic research. In this in vivo study, we investigated cell (osteocyte, fibroblast, and keratinocyte) adhesion and penetration into the pores of a titanium pylon implanted in Wistar rats. The porous titanium pylon was implanted in the bone of the thigh residua of four rats. Electronic scanning and morphological analysis demonstrated integration of the pylon with the surrounding skin. These findings support the possibility of developing a natural barrier against the infection associated with direct skeletal attachment of limb prostheses.
Key words: amputation, animal model, cell adhesion, osseointegration, porous titanium, prosthetic pylon, rehabilitation, residuum, skin infection, skin ingrowth.

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