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Logo for the Journal of Rehab R&D
Volume 43 Number 7, November/December 2006
Pages 845 — 856


Abstract - Reliability of near-infrared spectroscopy measures of cerebral oxygenation and blood volume during handgrip exercise in nondisabled and traumatic brain-injured subjects

Yagesh Bhambhani, PhD;1* Ram Maikala, PhD;1 Mamdouh Farag, BSc;1 Gary Rowland, MSc1-2

1Faculty of Rehabilitation Medicine, University of Alberta, Edmonton, Alberta, Canada; 2Brain Injury Rehabilitation Program, Alberta Hospital Ponoka, Ponoka, Alberta, Canada
Abstract — We compared the test-retest reliability of near- infrared spectroscopy (NIRS) measures of cerebral oxygenation and blood volume during a rhythmic handgrip exercise in 13 nondisabled subjects and 25 subjects with moderate to severe traumatic brain injury (TBI). Subjects with TBI (average Glasgow Coma Scale score = 4.2, average time since injury = 21 mo) had completed an acute brain injury rehabilitation program. After 2 min of rest, each subject performed 60 s of maximal rhythmic handgrip contractions with the right hand in two trials 24 to 48 h apart. We used NIRS to measure cerebral oxygenation and blood volume responses from the left prefrontal lobe. Both groups' cerebral oxygenation and blood volume increased during handgrip contractions. The change in cerebral oxygenation was significantly lower in subjects with TBI compared with nondisabled subjects. Intraclass correlations between the two trials for cerebral oxygenation and blood volume were 0.83 and 0.80, respectively, in nondisabled subjects and 0.70 and 0.64, respectively, in subjects with TBI. The findings indicate that NIRS is a reliable noninvasive technique for evaluating cerebral oxygenation and blood volume changes during motor function. NIRS can be useful in monitoring recovery of cerebral oxygenation during rehabilitation of patients with TBI.
Key words: Bland-Altman analysis, blood volume, cerebral oxygenation, handgrip contractions, intraclass correlations, motor function, near infrared spectroscopy, rehabilitation, test-retest reliability, traumatic brain injury.

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