Volume 44 Number 5 2007
Pages 631 — 636

Abstract - Effects of vacuum-compression therapy on healing of diabetic foot ulcers: Randomized controlled trial

Asghar Akbari, PhD;1* Hesam Moodi, BSc;1 Fatemeh Ghiasi, MSc;1 Hamidreza Mahmoudzadeh Sagheb, PhD;2 Homayra Rashidi, MD3

Departments of    1Physiotherapy, Faculty of Paramedicine, 2Histology, and  3Internal Medicine, Faculty of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran

Abstract-A single-blind, randomized controlled trial was conducted to evaluate vacuum-compression therapy (VCT) for the healing of diabetic foot ulcers. Eighteen diabetic patients with foot ulcers were recruited through simple nonprobability sampling. Subjects were randomly assigned to either an experimental or a control group. Before and after intervention, the foot ulcer surface area was estimated stereologically, based on Cavalieri's principle. The experimental group was treated with VCT in addition to conventional therapy for 10 sessions. The control group received only conventional therapy, including debridement, blood glucose control agents, systemic antibiotics, wound cleaning with normal saline, offloading (pressure relief), and daily wound dressings. The mean foot ulcer surface area decreased from 46.88 +/- 9.28 mm2 to 35.09 +/- 4.09 mm2 in the experimental group (p = 0.006) and from 46.62 +/- 10.03 mm2 to 42.89 +/- 8.1 mm2 in the control group (p = 0.01). After treatment, the experimental group significantly improved in measures of foot ulcer surface area compared with the control group (p = 0.024). VCT enhances diabetic foot ulcer healing when combined with appropriate wound care.

Key words: Cavalieri's principle, conventional therapy, diabetic foot ulcer, healing, randomized controlled trial, rehabilitation, stereology, ulcer area, vasotrain, VCT.

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