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Early microglial inhibition preemptively mitigates chronic pain development after experimental spinal cord injury

Andrew M. Tan, PhD, et al.

Figure. Quantification of microglial activation.

Spinal cord injury (SCI) can result in chronic pain syndromes that can persist indefinitely and reduce quality of life. Treatment of chronic pain after SCI remains extremely challenging; thus, an important research goal is to determine whether early treatments can attenuate the subsequent development of pain conditions. This study examines the effects of SCI on chronic pain by using a drug that inhibits the activation of a cell type called microglia. We found that microglial inhibition soon after injury diminished development of pain at later time points and that modulation of microglial signaling may provide a new therapeutic strategy for patients suffering from post-SCI pain.


Volume 46 Number 1, 2009
   Pages 123 — 134


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