Logo for the Journal of Rehab R and D

Volume 46 Number 3, 2009
   Pages 315 — 330

Abstract – Mathematical modeling and mechanical and histopathological testing of porous prosthetic pylon for direct skeletal attachment

Mark Pitkin, PhD;1-2* Grigory Raykhtsaum, MS;2 John Pilling, PhD;3 Yuri Shukeylo, PhD;4 Vladimir Moxson, PhD;5 Volodimir Duz, PhD;5 John Lewandowski, PhD;6 Raymond Connolly, PhD;1 Robert S. Kistenberg, MPH, CP, FAAOP;7 John F. Dalton IV, MD;8 Boris Prilutsky, PhD;7 Stewart Jacobson, DVM, DACVP9

1Tufts University, Boston, MA; 2Poly-Orth International, Sharon, MA; 3Materials Science and Engineering, Michigan Technological University, Houghton, MI; 4St. Petersburg Electrotechnical University, St. Petersburg, Russia; 5ADMA Products Inc, Hudson, OH; 6Case Western Reserve University, Cleveland, OH; 7Georgia Institute of Technology, Atlanta, GA; 8Georgia Hand, Shoulder & Elbow, Atlanta, GA; 9Charles River Pathology Associates, Frederick, MD

Abstract — This article presents recent results in the development of the skin and bone integrated pylon (SBIP) intended for direct skeletal attachment of limb prostheses. In our previous studies of the porous SBIP-1 and SBIP-2 prototypes, the bond site between the porous pylons and residuum bone and skin did not show the inflammation characteristically observed when solid pylons are used. At the same time, porosity diminished the strength of the pylon. To find a reasonable balance between the biological conductivity and the strength of the porous pylon, we developed a mathematical model of the composite permeable structure. A novel manufacturing process was implemented, and the new SBIP-3 prototype was tested mechanically. The minimal strength requirements established earlier for the SBIP were exceeded threefold. The first histopathological analysis of skin, bone, and the implanted SBIP-2 pylons was conducted on two rats and one cat. The histopathological analysis provided new evidence of inflammation-free, deep ingrowth of skin and bone cells throughout the SBIP structure.

Key words: arthroplasty, bone, direct skeletal attachment, infection, limb amputation, osseointegration, porous pylon, prosthetic rehabilitation, skin, skin and bone integrated pylon.

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