At a glance - Multivariate models of determinants of health-related quality of life in severe chronic obstructive pulmonary disease

JRRD at a Glance

Multivariate models of determinants of health-related quality of life in severe chronic obstructive pulmonary disease

Marilyn L. Moy, MD, MSc, et al.

Persons with severe chronic obstructive pulmonary disease (COPD) and similar levels of lung function, exercise capacity, and dyspnea have a wide range of health-related quality of life (HRQL). We show that although lung function, exercise capacity, and dyspnea significantly correlate with HRQL, their effects are reduced when other psychosocial and clinical variables are considered. Prior participation in pulmonary rehabilitation and supplemental oxygen use are associated with better HRQL. Self-perception of being disabled, depression, oral corticosteroid use, and daytime sleepiness are associated with worse HRQL. To optimize HRQL in severe COPD, doctors should pay attention to a number of clinical and physiological factors.

Volume 46 Number 5, 2009
Pages 643 — 654

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