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Sleep apnea, apolipoprotein epsilon 4 allele, and TBI: Mechanism for cognitive dysfunction and development of dementia

Ruth O'Hara, PhD, et al.

This article provides an overview of the literature on traumatic brain injury (TBI) and sleep apnea. We present evidence to suggest that these factors in combination with the presence of the apolipoprotein epsilon 4 allele may contribute significantly to cognitive dysfunction and the development of dementia. Because the majority of sleep apnea patients are male and TBI is common among veterans because of combat and other factors, this work has significant importance for the Department of Veterans Affairs.

Volume 46 Number 6, 2009
   Pages 837 — 850

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