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Advances in neuroimaging of traumatic brain injury and posttraumatic stress disorder

Robert W. Van Boven, MD, DDS, et al.

Figure 6. Positron emission tomography (PET) amyloid-beta (Abeta) plaque example. Increased retention of tracer in right frontal cortical area is seen over 2 years during which 74-year-old subject remained cognitively normal.

Improved diagnosis and treatment of traumatic brain injury (TBI) and posttraumatic stress disorder (PTSD) are needed. Nearly one out of every five Operation Iraqi Freedom/Operation Enduring Freedom servicemembers (300,000) suffers from symptoms of PTSD or depression and 320,000 may have sustained TBI (mostly mild). Although most patients with mild TBI recover fully, a significant number have persistent problems with memory, concentration, irritability, and headaches. In mild TBI, usual brain images do not show abnormalities. This article reviews advanced imaging studies aimed at better detecting brain changes that may help us understand and treat patients with TBI and PTSD.


Volume 46 Number 6, 2009
   Pages 717 — 756


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