Journal of Rehabilitation Research & Development (JRRD)

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Iontophoretic delivery of nitric oxide donor improves local skin flap viability

John A. Russell, MS, et al.

Figure 1.Representative photograph of increased tissue survival notedfollowing injection of nitric oxide donor DETA-NO. Arrows desig-nate line of necrosis. (a) Control flap. (b) DETA-NO treated flap.DETA-NO = diethylenetriamine NONOate.

This research will help develop a new technique for treating serious medical problems in combat veterans. Effective methods for treating hypoxic wounds will promote healing of trauma sites and wounds caused by replanted/transplanted tissues. This new method will promote improved wound healing, reduce the chance of infection, and reduce risk the of tissue death. Benefits to combat veterans include the method's portability, appropriateness for use in the field, and inexpensive cost. Veterans sustaining difficult wartime wounds will heal faster and safer if complications due to wound healing can be eliminated by this new technique.

Volume 47 Number 1, 2010
   Pages 61 — 66

View HTML  ¦  View PDF  ¦  Contents Vol. 47, No. 1