Journal of Rehabilitation Research & Development (JRRD)

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Volume 47 Number 5, 2010
   Pages 477 — 484

Abstract — Novel method for measurement of fatigue in multiple sclerosis: Real-Time Digital Fatigue Score

Edward Kim, MD;1-2* Jesus Lovera, MD, MsPH;3 Laura Schaben, MD;1-2 J. Melara, MPH;3 Dennis
Bourdette, MD;1-2 Ruth Whitham, MD1-2

1Department of Neurology, School of Medicine, Oregon Health & Science University, Portland, OR; 2Multiple Sclerosis Center of Excellence-West, Portland Department of Veterans Affairs Medical Center, Portland, OR; 3Department of Neurology, School of Medicine, Louisiana State University Health Sciences Center-New Orleans, New Orleans, LA

Abstract — The study's objective was to develop a real-time measurement for fatigue and to evaluate whether it is an effective clinical trial outcome measure compared with the Fatigue Severity Scale (FSS) and the Modified Fatigue Impact Scale (MFIS). Forty-nine subjects with MS and an FSS >4 recorded Real-Time Digital Fatigue Scores (RDFSs) on a wrist-worn device four times a day over 3 weeks. Scores were scaled 0-10, with 10 representing the worst possible fatigue. FSS and MFIS were evaluated and compared with RDFSs. Mean RDFSs significantly correlated with FSS (r = 0.55, p < 0.001) and MFIS (r = 0.55, p < 0.001). RDFS captured circadian variations in fatigue, with scores increasing from mean 3.4 at 9 a.m., to 4.0 at 1 p.m., 4.5 at 5 p.m., and 5.0 at 9 p.m. When all scores over all days were included in a mixed-model analysis of circadian variation, the differences in RDFS between times were more significant than in an analysis that included only single scores of data isolated from the first day of monitoring. RDFS is a promising measure. RDFS significantly correlated with FSS and MFIS, captured real-time daily and circadian variations in fatigue, and provided multiple measurements of fatigue that provided statistical advantages over FSS and MFIS.

Key words: assessment, disability, fatigue, Fatigue Severity Scale, ginseng, Modified Fatigue Impact Scale, multiple sclerosis, outcome measures, questionnaires, rating scales.

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Last Reviewed or Updated  Wednesday, July 28, 2010 9:37 AM

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