Journal of Rehabilitation Research & Development (JRRD)

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Arthroplasty in veterans: Analysis of cartilage, bone, serum, and synovial fluid reveals differences and similarities in osteoarthritis with and without comorbid diabetes


Figure 1. Pentosidine content of bone and cartilage tissue obtained from totalknee arthroplasty. Black bars represent diabetes mellitus (DM) group,and light gray bars represent non-DM group.

Diabetes affects 20% of patients in the Department of Veterans Affairs Healthcare System and is known to harm many parts of the body, including the bones and joints. This study measured the biological differences in bone and cartilage taken from total knee joint replacement surgeries of osteoarthritis patients with or without diabetes. We found that diabetes can harm these tissues, making osteoarthritis worse (and leading to earlier surgery) and/or slowing down bone repair after surgery. Clinicians should be aware that for bone healing, current blood glucose levels may be less important than long-term glycemic control. In summary, diabetes has some harmful effects on the health of veterans with osteoarthritis.

Volume 48 Number 10, 2011
   Pages 1195 — 1210


View HTML  ¦  View PDF  ¦  Contents Vol. 48, No. 10
This article and any supplementary material should be cited as follows:
Oren TW, Botolin S, Williams A, Bucknell A, King KB. Arthroplasty in veterans: Analysis of cartilage, bone, serum, and synovial fluid reveals differences and similarities in osteoarthritis with and without comorbid diabetes. J Rehabil Res Dev. 2011;48(10):1195???1210.
DOI:10.1682/JRRD.2010.09.0186
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Last Reviewed or Updated  Tuesday, March 20, 2012 11:21 AM

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