Journal of Rehabilitation Research & Development (JRRD)

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Volume 48 Number 10, 2011
   Pages 1195 — 1210

Abstract — Arthroplasty in veterans: Analysis of cartilage, bone, serum, and synovial fluid reveals differences and similarities in osteoarthritis with and without comorbid diabetes

Trevor W. Oren, MD;1???2 Sergiu Botolin, MD, PhD;1 Allison Williams, ND, PhD, RN;1???2 Allan Bucknell, MD;1???2 Karen B. King, PhD1???2*

1Department of Orthopaedics, University of Colorado School of Medicine, Aurora, CO; 2Eastern Colorado Health Care System, Department of Veterans Affairs, Denver, CO
Abstract???Osteoarthritis patients with diabetes who receive total knee arthroplasty are more vulnerable to complications, including aseptic loosening and need for revision surgery. To elucidate mechanisms related to arthroplasty failure in diabetes, we examined serum and synovial fluid markers as well as collagen crosslinks in bone and cartilage of 20 patients (10 with diabetes, 10 controls without) undergoing this procedure. Hemoglobin A1c, body mass index, bone alkaline phosphatase, leptin, osteocalcin, and pyridinium were analyzed along with tissue content of the crosslinks hydroxylysylpyridinoline, lysylpyridinoline, and pentosidine. Pentosidine levels in tissue specimens from diabetic subjects were higher than in control subjects. Osteocalcin levels negatively correlated with hydroxylysylpyridinoline levels in cartilage. Osteocalcin levels also negatively correlated with pentosidine levels in cartilage, but only in subjects with diabetes. This study suggests potential metabolic mechanisms for arthroplasty failure in patients with diabetes.
Key words: arthroplasty, bone, cartilage, collagen, diabetes, leptin, osteoarthritis, osteocalcin, pentosidine, veterans.

View HTML  ¦  View PDF  ¦  Contents Vol. 48, No. 10
This article and any supplementary material should be cited as follows:
Oren TW, Botolin S, Williams A, Bucknell A, King KB. Arthroplasty in veterans: Analysis of cartilage, bone, serum, and synovial fluid reveals differences and similarities in osteoarthritis with and without comorbid diabetes. J Rehabil Res Dev. 2011;48(10):1195???1210.
DOI:10.1682/JRRD.2010.09.0186
Crossref

Last Reviewed or Updated  Tuesday, March 20, 2012 11:23 AM

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