The formation and differentiation of blood vessels, known as angiogenesis, are important in wound healing and occur during the proliferative (rapid growth) phase. A potent direct angiogenic factor is the vascular endothelial growth factor (VEGF), which stimulates migration, proliferation, and/or tube formation of endothelial cells. We evaluated the effect of sensory and motor electrical stimulation (ES) on the release of VEGF in full-thickness wounds of rats (divided into three groups: sensory ES, motor ES, and control groups). We measured VEGF expression in muscle and skin of rats on days 3 and 7 after surgical incision. We found no difference in the values of VEGF among groups on day 3. However, on day 7, the values of skin VEGF in the sensory group were significantly greater than those values of the other groups. We found no difference among groups regarding the values of muscle VEGF on days 3 and 7. Apparently, sensory ES can induce more release of VEGF in skin and may effectively promote wound healing.
Volume 48 Number 3, 2011
Pages 195 — 202
Last Reviewed or Updated Tuesday, March 22, 2011 11:17 AM