Journal of Rehabilitation Research & Development (JRRD)

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Volume 48 Number 5, 2011
   Pages 555 — 564

Abstract —  Decreased central fatigue in multiple sclerosis patients after 8 weeks of surface functional electrical stimulation

Ya-Ju Chang, PhD;1* Miao-Ju Hsu, PhD;2 Shin-Man Chen, MS;1 Cheng-Hsiang Lin, PhD;3 Alice M. K. Wong, MD1

1Department of Physical Therapy and Graduate Institute of Rehabilitation Science, Chang Gung University, Taoyuan, Taiwan; 2Department of Physical Therapy, College of Health Science, Kaohsiung Medical University, and Department of Physical Medicine and Rehabilitation, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; 3Department of Statistics, Tunghai University, Taichung, Taiwan

Abstract —  Effective treatments for multiple sclerosis (MS)-associated central fatigue have not been established. Surface functional electrical stimulation (FES), which can challenge the peripheral neuromuscular system without overloading the central nervous system, is a relatively safe therapeutic strategy. We investigated the effect of 8 weeks of surface FES training on the levels of general, central, and peripheral fatigue in MS patients. Seven of nine individuals with MS (average age: 42.86 +/- 13.47 years) completed 8 weeks of quadriceps muscle surface FES training. Maximal voluntary contraction, voluntary activation level, twitch force, General Fatigue Index (FI), Central Fatigue Index (CFI), Peripheral Fatigue Index, and Modified Fatigue Impact Scale (MFIS) scores were determined before and after training. The results showed that FI (p = 0.01), CFI (p = 0.02), and MFIS (p = 0.02) scores improved significantly after training. Improvements in central fatigue contributed significantly to improvements in general fatigue (p < 0.01). The results of the current study showed that central fatigue was a primary limitation in patients with MS during voluntary exercise and that 8 weeks of surface FES training for individuals with MS led to significantly reduced fatigue, particularly central fatigue.

Key words: central fatigue, demyelinating disease, fatigue, functional electrical stimulation, interpolated twitch, maximum voluntary contraction, multiple sclerosis, peripheral fatigue, rehabilitation, twitch.


View HTML  ¦  View PDF  ¦  Contents Vol. 48, No. 5
This article and any supplementary material should be cited as follows:
Chang YJ, Hsu MJ, Chen SM, Lin CH, Wong AMK. Decreased central fatigue in multiple sclerosis patients after 8 weeks of surface functional electrical stimulation. J Rehabil Res Dev. 2011;48(5):555-64.
DOI:10.1682/JRRD.2010.03.0038
ResearcherID: Ya-Ju Chang, PhD: B-9326-2011.
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Last Reviewed or Updated  Tuesday, May 31, 2011 9:24 AM

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