Approximately 1.25 million individuals annually sustain burn injuries in the United States. Pain is frequent in patients with burn injuries and often does not respond to medication. We report results from 5 subjects who were burned on their limb(s) 8 weeks to 11 years previously. These subjects demonstrate reduced pain threshold to temperature outside the burn injury zone. These results complement data from animal models that demonstrate that pain can develop in locations outside of the region of a burn injury as a result of changes within the spinal cord and suggest that central mechanisms contribute to pain after burn injury.
Volume 49 Number 4, 2012
Pages 515 — 522
Last Reviewed or Updated Wednesday, May 30, 2012 10:15 AM