Journal of Rehabilitation Research & Development (JRRD)

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Volume 49 Number 4, 2012
   Pages 515 — 522

Abstract — Extraterritorial temperature pain threshold abnormalities in subjects with healed thermal injury

Tanya Z. Fischer, MD, PhD;* Stephen G. Waxman, MD, PhD
Department of Neurology and Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, CT; Rehabilitation Research Center, Department of Veterans Affairs Connecticut Healthcare System, West Haven, CT

Abstract — Approximately 1.25 million individuals sustain burn injuries annually in the United States. Pain is frequent in patients with burn injuries and is often refractory to pharmacotherapy. We report quantitative sensory data from five subjects who sustained external thermal injuries to their limb(s) 8 weeks to 11 years previously, demonstrating reduced thermal pain thresholds in regions outside the burn injury zone, including contralateral limbs. Warm and cold detection thresholds were not significantly different from controls. These results complement data from animal models that demonstrate that allodynia can develop contralateral to a focal burn injury as a result of changes within the spinal cord and suggest that systemic or central mechanisms contribute to pain after burn injury.

Keywords:allodynia, burn, extraterritorial, hyperalgesia, neuropathic pain, pain, pain threshold, sensitivity, sensory assessment, thermal injury.

View HTML  ¦  View PDF  ¦  Contents Vol. 49, No. 4
This article and any supplementary material should be cited as follows:
Fischer TZ, Waxman SG. Extraterritorial temperature pain threshold abnormalities in subjects with healed thermal injury. J Rehabil Res Dev. 2012;49(4):515–22.

Last Reviewed or Updated  Wednesday, May 30, 2012 10:28 AM

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