Journal of Rehabilitation Research & Development (JRRD)

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Pharmacotherapy for posttraumatic stress disorder: Review with clinical applications

Matthew Jeffreys, MD, et al.

Figure 1. Stepped care for pharmacotherapy in posttraumatic stress disor-der (PTSD). Adapted from Department of Veterans Affairs/Depart-ment of Defense Clinical Practice Guideline for Management of Post-Traumatic Stress. SNRI = serotonin-norepinephrine reuptake inhibitor, SSRI = selective serotonin reuptake inhibitor, TCA = tricyclic antidepressant, TX = treatment.

Posttraumatic stress disorder (PTSD) is a common mental health problem in veterans and often occurs with other medical and mental health problems. Evidencebased psychotherapy focusing on traumatic events is the most effective treatment for PTSD. Medications can provide additional or alternative treatment for some patients. This article provides practical guidance to clinicians based on the 2010 revised Department of Veterans Affairs/Department of Defense Clinical Practice Guideline for PTSD. Both first-line and second-line medications are discussed. Certain medications, such as benzodiazepines and antipsychotics, are not recommended in PTSD. The CPG provides evidenced-based interventions for PTSD treatment.

Volume 49 Number 5, 2012
   Pages 703 — 716


View HTML  ¦  View PDF  ¦  Contents Vol. 49, No. 5
This article and any supplementary material should be cited as follows:
Jeffreys M, Capehart B, Friedman MJ. Pharmacotherapy for posttraumatic stress disorder: Review with clinical applications. J Rehabil Res Dev. 2012;49(5):703–16.
http://dx.doi.org/10.1682/JRRD.2011.09.0183
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Last Reviewed or Updated  Wednesday, July 18, 2012 9:31 AM

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