Repeated blast exposures of mice showed significant alteration in multiple genes involved in age- or noiserelated hearing loss. Blast exposure also showed significant neuropathology in the auditory cortex, suggesting that blast exposure damages central auditory processing systems. Differentially expressed genes include otoferlin, otoancorin, cadherins, and calcium regulating proteins/ receptors, which are known to play various roles in auditory processing and hearing impairment. Changes in hearing-related gene expression after blast exposures need to be investigated further to draw specific biochemical pathways involved in defective central auditory processing leading to auditory dysfunction and tinnitus.
Volume 49 Number 7, 2012
Pages 1153 — 1162
This article and any supplementary material should be cited as follows:
Valiyaveettil M, Alamneh Y, Miller S, Hammamieh R, Wang Y, Arun P, Wei Y, Oguntayo S, Nambiar MP. Preliminary studies on differential expression of auditory functional genes in the brain after repeated blast exposures. J Rehabil Res Dev. 2012;49(7):1153-62.
Last Reviewed or Updated Wednesday, October 24, 2012 12:23 PM