Journal of Rehabilitation Research & Development (JRRD)

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Volume 49 Number 8, 2012
   Pages 1269 — 1276

Abstract — The Unified Parkinson’s Disease Rating Scale as a predictor of peak aerobic capacity and ambulatory function

Frederick M. Ivey, PhD;1–2* Leslie I. Katzel, MD, PhD;2–3 John D. Sorkin, MD, PhD;2–3 Richard F. Macko, MD;1–2 Lisa M. Shulman, MD1

1University of Maryland School of Medicine, Department of Neurology, Baltimore, MD; 2Division of Gerontology and Geriatric Medicine, Department of Veterans Affairs (VA) and VA Medical Center, Geriatric Research, Education and Clinical Center, Baltimore, MD; 3University of Maryland School of Medicine, Department of Medicine, Baltimore, MD

Abstract — The Unified Parkinson’s Disease Rating Scale (UPDRS) is a widely applied index of disease severity. Our objective was to assess the utility of UPDRS for predicting peak aerobic capacity (VO2 peak) and ambulatory function. Participants (n = 70) underwent evaluation for UPDRS (Total and Motor ratings), VO2 peak, 6-minute walk distance (6MW), and 30-foot self-selected walking speed (SSWS). Using regression, we determined the extent to which the Total and Motor UPDRS scores predicted each functional capacity measure after adjusting for age and sex. We also tested whether adding the Hoehn and Yahr scale (H-Y) to the model changed predictive power of the UPDRS. Adjusted for age and sex, both the Total UPDRS and Motor UPDRS subscale failed to predict VO2 peak. The Total UPDRS did weakly predict 6MW and SSWS (both p < 0.05), but the Motor UPDRS subscale did not predict these ambulatory function tests. After adding H-Y to the model, Total UPDRS was no longer an independent predictor of 6MW but remained a predictor of SSWS. We conclude that Total and Motor UPDRS rating scales do not predict VO2 peak, but that a weak relationship exists between Total UPDRS and measures of ambulatory function.

Key words: 6-minute walk distance, ambulatory function, disease severity, endurance, motor function, Parkinson disease, self-selected walking speed, UPDRS, VO2 peak, walking.


View HTML  ¦  View PDF  ¦  Contents Vol. 49, No. 8
This article and any supplementary material should be cited as follows:
Ivey FM, Katzel LI, Sorkin JD, Macko RF, Shulman LM. The Unified Parkinson’s Disease Rating Scale as a predictor of peak aerobic capacity and ambulatory function. J Rehabil Res Dev. 2012;49(8):1269–76.
http://dx.doi.org/10.1682/JRRD.2011.06.0103
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Last Reviewed or Updated  Tuesday, December 11, 2012 9:34 AM

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