Journal of Rehabilitation Research & Development (JRRD)

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Volume 50 Number 1, 2013
   Pages 17 — 30

Abstract — Effect of extremely low frequency magnetic field in prevention of spinal cord injury-induced osteoporosis

Jayanand Manjhi, PhD;1 Suneel Kumar, MSc;1 Jitendra Behari, PhD;2 Rashmi Mathur, PhD1*
1Department of Physiology, All India Institute of Medical Sciences, New Delhi, India; 2School of Environmental Sciences, Jawaharlal Nehru University (JNU), New Delhi, India

Abstract — The present study was designed to investigate the effect of extremely low frequency (ELF) magnetic field (MF) on spinal cord injury (SCI)-induced osteoporosis in rats. Adult male Wistar rats (n = 24) were equally divided into sham, SCI, and SCI+MF groups. Complete transection of spinal cord (thoracic 11 vertebra) was surgically performed under anesthesia, whereas in the sham group only laminectomy was done. Post-SCI day 1, rats were either exposed (2 h/d ?? 8 wk) to ELF-MF (17.96 micro-Tesla, 50 Hz; SCI+MF group) or sham exposed (SCI group). Basso, Beattie, and Bresnahan (BBB) score was recorded weekly. All the rats were sacrificed 8 wk post-SCI; tibia and femur bones were isolated for the analysis of bone mineral content (BMC; total calcium [Ca], phosphorus [P], carbon [C]), bone mineral density (BMD), and biochemical status (osteocalcin, collagen I, alkaline phosphatase). The BBB score decreased post-SCI, which partially recovered after ELF-MF. In SCI rats, there was a statistically significant decrease in BMC, Ca, P, C, BMD, and biochemical level in both the bones as compared with the sham group, which was attenuated in SCI+MF rats except the C content. Electron microscopic study revealed the enhancement of microstructural composition and compactness in cortical and trabecular parts of treated bones. The results suggest that the chronic (2 h/d ?? 8 wk) ELF-MF exposure (17.96 micro-Tesla, 50 Hz) to SCI rats is effective in attenuating SCI-induced osteoporosis.

Key words: alkaline phosphatase, BBB score, bone mineral contents, bone mineral density, collagen I, complete transection, extremely low frequency magnetic field, osteocalcin, osteoporosis, spinal cord injury.


View HTML  ¦  View PDF  ¦  Contents Vol. 50, No. 1
This article and any supplementary material should be cited as follows:
Manjhi J, Kumar S, Behari J, Mathur R. Effect of extremely low frequency magnetic field in prevention of spinal cord injury-induced osteoporosis. J Rehabil Res Dev. 2013;50(1):17–30.
http://dx.doi.org/10.1682/JRRD.2011.12.0248
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