Journal of Rehabilitation Research & Development (JRRD)

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Volume 50 Number 4, 2013
   Pages 455 — 462

Abstract — Prior housing conditions and sleep loss may affect recovery from brain injury in rats: A pilot study

Ronald G. Riechers, MD;1–2 Jaime L. Shuster, MA;1,3 Kathryn J. Bryan, PhD;1 Christopher J. Burant, PhD;4–5 Sherry L. Ball, PhD1,3,6*

1Louis Stokes Cleveland Department of Veterans Affairs Medical Center (VAMC), Cleveland, OH; 2Department of ??Neurology, Case Western Reserve University, Cleveland, OH; 3Department of Psychology, Cleveland State University, Cleveland, OH; 4Geriatric Research, Education and Clinical Center, Louis Stokes Cleveland VAMC, Cleveland, OH; 5Frances Payne Bolton School of Nursing, Case Western Reserve University, Cleveland, OH; 6Department of ??Ophthalmology, The Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH

Abstract — The purpose of this study is to understand the effect of combat-associated conditions such as sleep deprivation (SD) on subsequent traumatic brain injury (TBI). Prior to TBI (or sham surgery) induced by controlled cortical impact (CCI), rats were housed singly in chambers that prevented rapid eye movement sleep or allowed unrestricted sleep (no SD). Sensorimotor function was tested pre-SD and retested on postoperative days (PDs) 4, 7, and 14. Two additional control groups were housed socially prior to either CCI or sham surgery. CCI resulted in immediate performance deficits on sensorimotor tasks. The PD on which performance returned to baseline depended on preinjury conditions. Overall, preinjury SD+CCI resulted in an earlier recovery than no SD+CCI, and the no SD+CCI group (housed singly under conditions comparable with the SD group) recovered slower than all other groups. These data are the first to raise the possibility that recovery of sensorimotor function following TBI is affected by preinjury conditions. The data suggest that preinjury SD 24 h in duration may result in faster recovery and that novel or social isolation conditions may impede recovery. Thus, the combat environment may contribute to complexities associated with TBIs common in U.S. servicemembers.

Key words: combat, controlled cortical impact, novel housing, premorbid conditions, sensorimotor function, sleep deprivation, social isolation, stress, trauma, traumatic brain injury.


View HTML  ¦  View PDF  ¦  Contents Vol. 50, No. 4
This article and any supplementary material should be cited as follows:
Riechers RG, Shuster JL, Bryan KJ, Burant CJ, Ball SL. Prior housing conditions and sleep loss may affect recovery from brain injury in rats: A pilot study. J Rehabil Res Dev. 2013;50(4):455–62.
http://dx.doi.org/10.1682/JRRD.2012.04.0061
ResearcherID/ORCID: Sherry L. Ball, PhD: C-9925-2013; Jaime L. Shuster, MA: C-9620-2013
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