Journal of Rehabilitation Research & Development (JRRD)

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Inflammation-mediating cytokine response to acute handcycling exercise with/without functional electrical stimulation-evoked lower-limb cycling

Thomas A. W. Paulson, MSc, et al.

Lower-limb paralysis and immobilization following a spinal cord injury predispose individuals to an elevation in cardiovascular disease risk factors; including chronic inflammation. Participation in regular exercise can reduce cardiovascular disease risk, in part because exercise may exert a down-regulatory effect on inflammatory pathways driving the development of insulin resistance and atherosclerosis. This study investigated whether the inflammation- mediating potential of handcycling exercise can be enhanced by the addition of concurrent electrical stimulation-evoked lower-limb cycling. Initial findings suggest electrical stimulation-evoked contractions initiated the secretion of the cytokine IL-6 from paralysed skeletal muscle and may enhance the antiinflammatory potential of acute upper-limb exercise.
http://dx.doi.org/10.1682/JRRD.2013.08.0184

Volume 51 Number 4, 2014
   Pages 645 — 654


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This article and any supplementary material should be cited as follows:
Paulson TA, Bishop NC, Smith BM, Goosey-Tolfrey VL. Inflammation-mediating cytokine response to acute handcycling exercise with/without functional electrical stimulation-evoked lower-limb cycling. J Rehabil Res Dev. 2014;51(4):645–54.
http://dx.doi.org/10.1682/JRRD.2013.08.0184
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