Journal of Rehabilitation Research & Development (JRRD)

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Intrinsic transient tracheal occlusion training and myogenic remodeling of rodent parasternal intercostal fibers

Barbara K. Smith, PhD, PT, et al.

This research has clinical implications for patients with weak respiratory muscles and dyspnea (shortness of breath). A rat model was used to identify fiber hypertrophy and regeneration in the parasternal intercostal muscles after 2 weeks of respiratory muscle training. The exercises increased parasternal fiber size equally and regeneration to a greater extent than the diaphragm. This work adds to our understanding of the cellular mechanisms by which respiratory muscle training improves muscle function. These findings may help providers prescribe to their patients the best type, frequency, and duration of exercise to improve inspiratory muscle function.
http://dx.doi.org/10.1682/JRRD.2012.12.0232

Volume 51 Number 5, 2014
   Pages 841 — 854


View HTML ¦ View PDF ¦ Contents Vol. 51, No.5

This article and any supplementary material should be cited as follows:
Smith BK, Mathur S, Ye F, Martin AD, Attia Truelson S, Vandenborne K, Davenport PW. Intrinsic transient tracheal occlusion training and myogenic remodeling of rodent parasternal intercostal fibers. J Rehabil Res Dev. 2014;51(5):841–54.
http://dx.doi.org/10.1682/JRRD.2012.12.0232
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