Journal of Rehabilitation Research & Development (JRRD)

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Effect of low-intensity direct current on expression of vascular endothelial growth factor and nitric oxide in diabetic foot ulcers

Mohammad Reza Mohajeri-Tehrani, MD, et al.

Diabetic foot ulceration is an important complication of diabetes. These ulcers are long-lasting open sores that are hard to heal because of poor blood circulation at the wound site. We studied how electrical stimulation affected levels of vascular endothelial growth factor and nitric oxide in the plasma of type 2 diabetic patients with foot ulceration. Electrical stimulation was delivered for 1 hour a day, 3 days a week, for 4 weeks (12 sessions total). Vascular endothelial growth factor and nitric oxide levels were significantly higher after the 12 sessions in the group who received electrical stimulation compared with an untreated group. Skin temperature increased significantly more in the electrical stimulation group than the untreated group. Application of electrical stimulation increases the expression of vascular endothelial growth factor and nitric oxide, which may improve blood flow, tissue temperature, and wound healing in patients with diabetic foot ulceration.
http://dx.doi.org/10.1682/JRRD.2013.08.0174

Volume 51 Number 5, 2014
   Pages 815 — 824


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Last Reviewed or Updated  Wednesday, September 3, 2014 9:55 AM

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