Journal of Rehabilitation Research & Development (JRRD)

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Volume 51 Number 7, 2014
   Pages 1047 — 1056

Abstract — Effects of hyperbaric oxygen on eye tracking abnormalities in males after mild traumatic brain injury

David X. Cifu, MD;1–2 Kathy W. Hoke, PhD;3 Paul A. Wetzel, PhD;4 Joanna R. Wares, PhD;3 George Gitchel, MS;4 William Carne, PhD1*

1Department of Physical Medicine and Rehabilitation, Virginia Commonwealth University, Richmond, VA; 2Physical Medicine and Rehabilitation Program Office, Department of Veterans Affairs, Richmond, VA; 3Department of Mathematics and Computer Science, University of Richmond, Richmond, VA; 4Department of Biomedical Engineering, Virginia Commonwealth University, Richmond, VA

Abstract — The effects of hyperbaric oxygen (HBO2) on eye movement abnormalities in 60 military servicemembers with at least one mild traumatic brain injury (mTBI) from combat were examined in a single-center, randomized, double-blind, sham-controlled, prospective study at the Naval Medicine Operational Training Center. During the 10 wk of the study, each subject was delivered a series of 40, once a day, hyperbaric chamber compressions at a pressure of 2.0 atmospheres absolute (ATA). At each session, subjects breathed one of three preassigned oxygen fractions (10.5%, 75%, or 100%) for 1 h, resulting in an oxygen exposure equivalent to breathing either surface air, 100% oxygen at 1.5 ATA, or 100% oxygen at 2.0 ATA, respectively. Using a standardized, validated, computerized eye tracking protocol, fixation, saccades, and smooth pursuit eye movements were measured just prior to intervention and immediately postintervention. Between- and within-groups testing of pre- and postintervention means revealed no significant differences on eye movement abnormalities and no significant main effect for HBO2 at either 1.5 ATA or 2.0 ATA equivalent compared with the sham-control. This study demonstrated that neither 1.5 nor 2.0 ATA equivalent HBO2 had an effect on postconcussive eye movement abnormalities after mTBI when compared with a sham-control.

Key words: blast injury, blinded, concussion, eye tracking, hyperbaric oxygen, postconcussive syndrome, randomized, saccades, sham controlled, traumatic brain injury.


View HTML ¦ View PDF ¦ Contents Vol. 51, No.7

This article and any supplementary material should be cited as follows:
Cifu DX, Hoke KW, Wetzel PA, Wares JR, Gitchel G, Carne W. Effects of hyperbaric oxygen on eye tracking abnormalities in males after mild traumatic brain injury. J Rehabil Res Dev. 2014;51(7):1047–56.
http://dx.doi.org/10.1682/JRRD.2014.01.0013
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