Journal of Rehabilitation Research & Development (JRRD)

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Reduced bone mass accrual in mouse model of repetitive mild traumatic brain injury

Hongrun Yu, PhD, et al.

Traumatic brain injury (TBI) is a major injury of combat operations. It is associated with serious mortality and morbidity for veterans. Its complications also include increased risk for osteoporosis and bone fractures. Since the majority of TBIs are mild cases, we evaluated the impact of mild TBI using a mouse model. This study revealed that TBI even in a mild form exerted significant negative effects on bone mass, bone structure, and bone strength. These results are instructive to clinicians who devise rehabilitation plans for veterans who have experienced TBI, indicating that these plans should also include the skeletal system.
http://dx.doi.org/10.1682/JRRD.2014.04.0095

Volume 51 Number 9, 2014
   Pages 1427 — 1438


View HTML ¦ View PDF ¦ Contents Vol. 51, No.9

This article and any supplementary material should be cited as follows:
Yu H, Wergedal JE, Rundle CH, Mohan S. Reduced bone mass accrual in mouse model of repetitive mild traumatic brain injury. J Rehabil Res Dev. 2014;51(9):1427???38.
http://dx.doi.org/10.1682/JRRD.2014.04.0095
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