Journal of Rehabilitation Research & Development (JRRD)

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Volume 52 Number 2, 2015
   Pages 159 — 170

Abstract — Lower-limb amputation and body weight changes in men

Alyson J. Littman, PhD;1–2* Mary Lou Thompson, PhD;1,3 David E. Arterburn, MD, MPH;4 Erin Bouldin, PhD;1–2 Jodie K. Haselkorn, MD;2,5–6 Bruce J. Sangeorzan, MD;6 Edward J. Boyko, MD1

1Seattle Epidemiologic Research and Information Center, Department of Veterans Affairs (VA) Puget Sound Health Care System, Seattle, WA; Departments of 2Epidemiology and 3Biostatistics, University of Washington, Seattle, WA; 4Group Health Research Institute, Seattle, WA; 5Multiple Sclerosis Centers of Excellence West, VA Puget Sound Health Care System, and Department of Rehabilitation, University of Washington, Seattle, WA; 6VA Center of Excellence for Limb Loss Prevention and Prosthetic Engineering, VA Puget Sound Health Care System, and Department of Orthopaedics and Sports Medicine, Harborview Medical Center, Seattle, WA

Abstract — Little is known about the relationship between lower-limb amputation (LLA) and subsequent changes in body weight. We conducted a retrospective cohort study using clinical and administrative databases to identify and follow weight changes in 759 males with amputation (partial foot amputation [PFA], n = 396; transtibial amputation [TTA], n = 267; and transfemoral amputation [TFA], n = 96) and 3,790 men without amputation frequency-matched (5:1) on age, body mass index, diabetes, and calendar year from eight Department of Veterans Affairs medical care facilities in the Pacific Northwest. We estimated and compared longitudinal percent weight change from baseline up to 39 mo of follow-up in men with and without amputation. Weight gain in the 2 yr after amputation was significantly more in men with an amputation than without, and in men with a TTA or TFA (8%–9% increase) than in men with a PFA (3%–6% increase). Generally, percent weight gain peaked at 2 yr and was followed by some weight loss in the third year. These findings indicate that LLA is often followed by clinically important weight gain. Future studies are needed to better understand the reasons for weight gain and to identify intervention strategies to prevent excess weight gain and the deleterious consequences that may ensue.

Key words: adult, lower-limb amputation, men, obesity, partial foot amputation, toe amputation, transfemoral amputation, transtibial amputation, Veterans, weight change.


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This article and any supplementary material should be cited as follows:
Littman AJ, Thompson ML, Arterburn DE, Bouldin E, Haselkorn JK, Sangeorzan BJ, Boyko EJ. Lower-limb amputation and body weight changes in men. J Rehabil Res Dev. 2015;52(2):159–70.
http://dx.doi.org/10.1682/JRRD.2014.07.0166
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