Journal of Rehabilitation Research & Development (JRRD)

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Volume 52 Number 6, 2015
   Pages 713 — 724

Abstract — Core muscle characteristics during walking of patients with multiple sclerosis

Nathaniel B. Ketelhut, BS;1 John H. Kindred, MS;1 Mark M. Manago, MS;2 Jeffrey R. Hebert, PhD;2 Thorsten Rudroff, PhD1*

1Department of Health and Exercise Science, Colorado State University, Fort Collins, CO; 2School of Medicine, University of Colorado Denver, Denver, CO

Abstract —  The purpose of this study was to investigate core muscle characteristics during walking in patients with multiple sclerosis (MS). Eight patients (4 men) with relapsing-remitting MS (aged 44.9 +/– 8.6 yr) and sex-matched controls (37.9 +/– 8.4 yr) walked on a treadmill for 15 min at a self-selected speed. Positron emission tomography/computed tomography imaging was u sed to measure core muscle activity immediately after walking based on glucose uptake. Activity was not different between the MS and control group for any of the identified muscles (p > 0.28). Within the MS group, side differences in activity were identified in the lateral flexor group, the external and internal obliques, and the rectus abdominis (p < 0.05), with the less-affected side being activated more. Furthermore, greater muscle volume was found on the more-affected side of the transversus abdominis, quadratus lumborum, and the low-back extensor group (p < 0.03). These muscle characteristics suggest patients with MS utilize compensatory mechanisms during walking to maintain balance and posture. These strategies likely result in increased muscle energy cost and early fatigability.

Key words: autoimmune disease, balance, computed tomography, disability, glucose uptake heterogeneity, muscle activation, muscle activity, muscle volume, positron emission tomography, stability, trunk.


View HTML ¦ View PDF ¦ Contents Vol. 52, No.6

This article and any supplementary material should be cited as follows:
Ketelhut NB, Kindred JH, Manago MM, Hebert JR, Rudroff T. Core muscle characteristics during walking of patients with multiple sclerosis. J Rehabil Res Dev. 2015; 52(6):713–24.
http://dx.doi.org/10.1682/JRRD.2015.01.0006
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