Journal of Rehabilitation Research & Development (JRRD)

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Volume 53 Number 2, 2016
   Pages 199 — 206

Abstract — Prediction of oxygen uptake during walking in ambulatory persons with multiple sclerosis

Stamatis Agiovlasitis, PhD;1* Brian M. Sandroff, MS;2 Robert W. Motl, PhD2

1Department of Kinesiology, Mississippi State University, Mississippi State, MS; 2Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, Urbana, IL

Abstract — People with multiple sclerosis (MS) have an increased rate of gross oxygen uptake (gross-VO2) during treadmill walking, and their gross-VO2 may further vary with walking impairment. This study attempted to develop an equation for predicting gross-VO2 from walking speed and an index of walking impairment in persons with MS and examine its accuracy. Gross-VO2 was measured with open-circuit spirometry in 43 persons with MS (47 +/– 9 yr; 38 women) during five treadmill walking trials, each lasting 6 min, at 2.0, 2.5, 3.0, 3.5, and 4.0 mph (0.89, 1.12, 1.34, 1.56, and 1.79 m/s). The 12-Item Multiple Sclerosis Walking Scale (MSWS-12) and the single-item Patient Determined Disease Steps scale (PDDS) provided indices of walking impairment. Multilevel modeling with random intercepts and slopes showed significant effects of speed and MSWS-12 on gross-VO2 (p </= 0.014; R2 = 0.70). PDDS was not a significant predictor. Gross-VO2 estimated by the regression equation did not differ from actual gross-VO2 across speeds. Mean absolute prediction error across speeds was 9.1%. The Bland-Altman plot indicated zero mean difference between actual and predicted gross-VO2 with modest 95% confidence intervals. Therefore, speed and MSWS-12 score are jointly highly predictive of gross-VO2 during treadmill walking in persons with MS.

Key words: ambulation, disability, energy expenditure, exercise, gait, impairment, neuropathy, physical activity, regression equation, rehabilitation.


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This article and any supplementary material should be cited as follows:
Agiovlasitis S, Sandroff BM, Motl RW. Prediction of oxygen uptake during walking in ambulatory persons with multiple sclerosis. J Rehabil Res Dev. 2016;53(2): 199–206.
http://dx.doi.org/10.1682/JRRD.2014.12.0307
ORCID: Stamatis Agiovlasitis, PhD: 0000-0003-2307-219X
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