Journal of Rehabilitation Research & Development (JRRD)

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An exploratory pilot investigation of neurosteroids and self-reported pain in female Iraq/ Afghanistan-era Veterans

Jennifer C. Naylor, PhD, et al.

Safe and effective medications for pain disorders are limited. Males and females may experience pain differently; however, little is known about the biology of pain disorders. Evidence suggests that neurosteroids (naturally occurring substances in the brain and body) may play a role in the biology of pain. Our preliminary findings show that DHEAS (neurosteroid) is lower in women who report higher levels of back pain. This could mean that women with lower DHEAS levels are at greater risk of developing pain than women with higher levels of DHEAS. Therefore, increasing DHEAS levels may prevent or improve pain in female Veterans.
http://dx.doi.org/10.1682/JRRD.2014.11.0294

Volume 53 Number 4, 2016
   Pages 499 — 510


View HTML ¦ View PDF ¦ Contents Vol. 53, No.4

This article and any supplementary material should be cited as follows:
Naylor JC, Kilts JD, Strauss JL, Szabo ST, Dunn CE, Wagner HR, Hamer RM, Shampine LJ, Zanga JR; Department of Veterans Affairs Mid-Atlantic Mental ??Illness Research, Education, and Clinical Center Workgroup; Marx CE. An exploratory pilot investigation of neurosteroids and self-reported pain in female Iraq/Afghanistan-era Veterans. J Rehabil Res Dev. 2016;53(4):499–510.
http://dx.doi.org/10.1682/JRRD.2014.11.0294
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